Clomid

Clomid (clomiphene citrate, or clomiphene), is a structural analogue of estrogens, and inhibits their action by preferentially binding to the receptor of the hypothalamic neuron normally intended for the reception of estrogen hormones. This makes clomiphene a competitive inhibitor of estrogens at the level of hypothalamic receptors. Clomiphene can be used alone in combination with metformin to induce ovulation in infertile women by follicular insufficiency, corresponding to a failure of estradiol production by the ovarian cortex.

A form of infertility is treated in women (follicular insufficiency): the follicles stimulated will grow until only one of them, the follicle of De Graaf, expels the oocyte in the fallopian tube. It is part of the list of essential medicines of the World Health Organization (list updated in April 2013).

Clomid is used in the treatment of anovularia associated with alterations of the luteinic phase or due to oligomenorrhea, secondary amenorrhea and polycystic ovary. By inhibiting the negative feedback of estrogen on the hypothalamus, it will stimulate the production of GnRH (gonadotropin-releasing hormone), increasing the production of FSH in the pituitary gland itself. The production of FSH will result, at the level of the ovary, in the increase of the secretion of sex hormones, which will allow the correct course of folliculogenesis. This control also acts on the ovarian follicle contained in the ovary, which it will stimulate.

The therapeutic efficacy of clomiphene citrate contained in Clomid is associated with its dual activity, both mildly estrogenic and anti-estrogenic.

This particular biological characteristic allows the aforementioned active principle to bind to estrogen receptors present at the hypothalamic and pituitary level with high affinity, inhibiting the negative feedback normally exerted by estrogens.

In this way the GnRH axis – Gonadotropins (FSH and LH) – estrogens, remains active, guaranteeing follicular maturation and subsequent ovulation, thus facilitating the establishment of a pregnancy.

Ovarian stimulation cycles should last 5 days, with the daily intake of one tablet. In the event of ovulatory failure, the same cycle could be repeated 2 more times with higher dosages and under strict medical supervision. Each phase of the therapy, from the definition of the dosage to the end of the cycle, should be supervised by your doctor.

The important efficacy of Clomid treatment lies in the advantageous pharmacokinetic properties of clomiphene citrate, which allow the patient to take the tablet orally, and the active principle to be easily absorbed at the intestinal level, and thus distributed in the circulation, to be eliminated afterwards a half-life of about 5 days mainly with feces.

The appearance of side effects on the visual apparatus, fogginess and opacification, could make the driving of vehicles or the use of machinery dangerous.

Despite the short duration of the treatment can significantly reduce the risk of side effects related to the use of clomiphene citrate, it is possible that therapy with Clomid may be associated with the appearance of:

• nausea
• vomiting
• nervousness
• fatigue
• headache
• visual changes
• increase in volume of ovaries and ovarian cysts
• abdominal tension
• abdominal pain
• vasomotor disorders
• increased breast tension with tenderness

Fortunately, the aforementioned symptoms tend to reverse easily once the therapy is suspended.

Before undertaking ovarian stimulation processes with clomiphene citrate, it is appropriate to characterize the reason for anovulation in physio-pathological terms and verify that the causes are compatible with the therapeutic indications provided for Clomid.

For this reason it is essential to supervise a specialist doctor in defining the treatment and throughout the therapeutic process. Moreover, the intake of clomiphene citrate, even if indirectly, could determine a volumetric increase of ovarian and cyst ovaries as well as an ovarian hyperstimulation syndrome, such as to require the rapid suspension of therapy.

Statistical data describe how the incidence of twin pregnancies is more frequent in women undergoing ovarian stimulation.

At the moment, given also the short periods of treatment, active ingredients are not known, whose intake, together with that of clomiphene citrate, could determine the onset of clinically relevant interactions.

The use of Clomid is contraindicated in women with menometrorrhagia, changes in liver function, pregnancy and lactation or in case of hypersensitivity to the active substance or one of its excipients.

Clomid contains lactose therefore it is contraindicated in patients with galactose intolerance, lactase enzyme deficiency or glucose-galactose malabsorption.

The scientific literature reports numerous studies carried out on experimental animal models, in which the intake of clomiphene citrate has contributed to the appearance in the fetus of evident malformations, concentrated above all on the genital, gastrointestinal and nervous apparatus, such as to compromise the survival of the fetus. It is also useful to remember how the intake of this active ingredient during lactation could inhibit milk production.

• Clominova – Pharma Synth Formulations Ltd.
• Clomiriv – EAST AFRICAN(INDIA) REMEDIES PVT.LTD
• Clomitrop – Modi Mundipharma Ltd.
• Clopreg – Kee Pharma Ltd.
• Fertomid – Cipla Limited
• Ferton Inga Laboratories Pvt. Ltd
• Fertilin Ind-Swift Limited
• Fertitone Western Remedies (India)
• Fertyl Ar-Ex Laboratories Pvt. Lltd.
• Fission – Biocin Genetics & Pharma
• Fulfyn – Micro Labs Ltd (India)
• Infotyl – Shreeyam Health Care
• Ovipreg – Win Medicare Limited
• Ovuclom – VHB Lifesciences Inc. (Cronus)
• Rejun – Uni Sankyo Ltd.

Before you proceed to look for opportunities to buy Clomid over the counter, you should be informed that this is a prescription drug. It is essential that you seek medical advice before you initiate the therapy with clomiphene citrate.

Clomid generics, as well as the original drug, can be ordered online for a fraction for the price established for the same preparation in the pharmacies of your city. This can be explained by a large number of marketing reasons. By ordering Clomid from an online pharmacy, you agree to terms and policies of its use, so you should familiarize yourself with them in advance. Look for a pharmacy whose policies pursue customer interests first and foremost; there should also be medical services provided if they do not require prescription to be presented when ordering legend drugs, to which Clomid belongs.